What causes mutton fat Keratic precipitates?

An exam of the anterior chamber typically shows keratic precipitates (KPs), representing leukocyte deposits on the posterior cornea. Granulomatous uveitis causes large KPs appearing like fat globules, named mutton-fat KPs, which suggest tuberculosis, syphilis, or sarcoidosis.

What causes Keratic precipitates?

Keratic precipitates (KPs) are corneal endothelial deposits that are frequently observed in association with anterior segment inflammation. These precipitates are formed by the aggregation of polymorphonuclear cells, lymphocytes, and epitheloid cells.

What cells comprise mutton fat KP?

Mutton-fat KPs are large in shape and are greasy-white in color and are formed from macrophages and epithelioid cells. They are indicative of inflammatory disease. Mutton fat KPs are due to granulomatous iridocyclitis.

What causes granulomatous uveitis?

Granulomatous uveitis tends to be chronic and is often associated with systemic conditions and autoimmune reactions. It may also be associated with infectious etiologies such as syphilis, Lyme disease, tuberculosis (TB), and herpetic viral infections.

What’s between lamb and mutton?

A sheep in its first year is a lamb and its meat is also lamb. The meat from sheep in their second year is hogget. Older sheep meat is mutton.

What is uvea of the eye?

The uvea consists of the layer and structures of the eye beneath the white of the eye (sclera).

What is Episcleritis in the eye?

Episcleritis is an inflammatory condition affecting the episcleral tissue between the conjunctiva (the clear mucous membrane lining the inner eyelids and sclera) and the sclera (the white part of the eye) that occurs in the absence of an infection.

How is granulomatous uveitis treated?

Topical corticosteroids are the mainstay of therapy and should be used aggressively during the initial phases of therapy. If the patient poorly complies with topical therapy or if the iritis is not responding to topical corticosteroids, a subconjunctival injection of shorter-acting or depot steroids may be used.

What causes mutton fat keratic precipitates ( KP )?

Mutton-Fat Keratic Precipitates (KP) KP are collections of inflammatory cells on the corneal endothelium. When these coalesce and become large with a yellowish color, they are described as mutton-fat KP. These are typically associated with granulomatous inflammation.

What are the signs of mutton fat keratic?

Mutton-fat keratic precipitates A characteristic of granulomatous inflammation Signs: White, yellowish greasy precipitates of inflammatory cells Causes of granulomatous uveitis may include sarcoidosis, Vogt-Koyanagi-Harada syndrome, multiple sclerosis, tuberculosis and syphilis.

What kind of inflammatory cells are mutton fat?

KP are collections of inflammatory cells on the corneal endothelium. When these coalesce and become large with a yellowish color, they are described as mutton-fat KP. These are typically associated with granulomatous inflammation.

What causes granulomatous uveitis in mutton fat?

Causes of granulomatous uveitis may include sarcoidosis, Vogt-Koyanagi-Harada syndrome, multiple sclerosis, tuberculosis and syphilis.