Is HCV genotype 1a curable?

With PEG/ribavirin treatment alone, genotype 1 HCV used to require the longest duration of treatment with the least likelihood of success. With sofosbuvir, genotype 1 is now curable in more than 95 percent of people treated for only 12 weeks.

What is the treatment for Hep C genotype 1a?

For HCV genotype 1a infected, treatment-naïve patients or patients who do not have cirrhosis, or in whom prior INF and RBV treatment has failed, there are three regimens of comparable efficacy: (1) daily fixed-dose combination of Ledipasvir/Sofosbuvir for 12 weeks, (2) daily fixed-dose combination of Paritaprevir/ …

What are the HCV genotypes?

The major HCV genotype worldwide is genotype 1, which accounts for 40%-80% of all isolates. Genotype 1 also may be associated with more severe liver disease and a higher risk of hepatocellular carcinoma. Genotypes 1a and 1b are prevalent in the United States, whereas in other countries, genotype 1a is less frequent.

Does Hep C shorten your life?

People with hepatitis C can live many years after diagnosis, but the range varies. A 2014 study showed that patients infected with hepatitis C virus died on average 15 years sooner than people who did not have the illness. With hepatitis C, the liver becomes seriously damaged due to inflammation.

What are the six genotypes?

A description of the pair of alleles in our DNA is called the genotype. Since there are three different alleles, there are a total of six different genotypes at the human ABO genetic locus. The different possible genotypes are AA, AO, BB, BO, AB, and OO.

What is HCV genotype test?

When used to determine the best treatment for HCV, a genotype test result identifies the strain of hepatitis C detected in the test sample. Doctors consider the virus’s strain as well as the health of the patient’s liver and other factors when determining treatment.

Which hepatitis is not curable?

Hepatitis B is a liver infection caused by a virus (called the hepatitis B virus, or HBV). It can be serious and there’s no cure, but the good news is it’s easy to prevent.

What are the treatments for hepatitis C?

The most common treatment for chronic hepatitis C is a combination of highly active antiviral agents known as direct-acting antivirals (DAAs). These new medications target specific components in the HCV replication cycle, preventing further infection and leading to viral clearance.

What is HCV genotype 1b?

HCV genotype 1 is the most common genotype in the US and Europe, accounting for 60% to 70% of HCV. HCV genotype 1a is more common than 1b in the US. 3. Genotype 1 and 3 infection are associated with more aggressive liver disease, with increased risk for cirrhosis and fibrosis, as well as greater risk for hepatocellular carcinoma.

What is hepatitis C 1A?

Hepatitis C genotype 1a, 1b. Throughout the world, Hepatitis C is subcategorized into six unique genotypes accompanied by several other subgenotypes. However, at present, a large number of people are known to be infected with hepatitis c genotype 1. In fact, genotype 1 is the most prevalent among all the types of the Hepatitis C genotypes virus.