Who is Jod-Basedow?

Jod-Basedow syndrome, also known as iodine-induced hyperthyroidism, is a rare cause of thyrotoxicosis typically seen after the administration of exogenous iodine.

Why is iodine called Jod?

The Jod-Basedow effect is named for the German word for iodine, “Jod” (all nouns are capitalized in German, and German cognates of English nouns with an initial letter “I” preceding a vowel are frequently spelled with initial “J”, pronouned as “ee”, thus “Jod” = “EE-ode”), plus the name of Karl Adolph von Basedow, a …

What causes Wolff-Chaikoff effect?

Iodine Deficiency and Iodine Excess Hypothyroidism can be caused by iodine deficiency (see Chapter 88) or iodine excess. Inorganic iodide in excess of daily doses of 500 to 1000 mcg inhibits organification of iodide, known as the Wolff-Chaikoff effect.

What is iodine induced hyperthyroidism?

Iodine-induced hyperthyroidism, or Jod-Basedow phenomenon, a thyrotoxic condition caused by exposure to increased amounts of iodine, has historically been reported in regions deficient in iodine.

What is Plummer’s disease?

Plummer disease, also known as toxic multinodular goiter, is a hormonally active multinodular goiter with hyperthyroidism. Plummer disease is the second most common cause of hyperthyroidism.

What is myxedema disease?

Myxedema is another term for severely advanced hypothyroidism. This is a condition that occurs when your body doesn’t produce enough thyroid hormone. The thyroid is a small gland that sits right at the front of your neck. It releases hormones that help your body regulate energy and control a wide variety of functions.

What is Plummer disease?

What is Thyroid storm?

Thyroid storm is a very rare, but life-threatening condition of the thyroid gland that develops in cases of untreated thyrotoxicosis (hyperthyroidism, or overactive thyroid). The thyroid gland is located in the neck, just above where your collarbones meet in the middle.

What is thyroid paradox?

Thyroid peroxidase test is a test that measures the level of an antibody that is directed against thyroid peroxidase (TPO). Autoantibodies to thyroid peroxidase (TPOAb) are produced within the body. The presence of TPOAb in the blood reflects a prior attack on the thyroid tissue by the body’s immune system.

Is iodine induced hyperthyroidism reversible?

Recently, iodine-induced reversible hypothyroidism has been well documented mostly by Japanese investigators. Reversible hypothyroidism occurs occasionally at the recovery phase of postpartum hypothyroidism, subacute thyroiditis, and painless thyroiditis. Such cases were excluded by the patients’ history.

How do you fix iodine induced hyperthyroidism?

Most cases of iodine-induced hyperthyroidism are self-limited and resolve successfully a few months after cessation of exposure. However, in some cases of severe and refractory hyperthyroidism, antithyroid drug treatment has been required, usually with high doses of methimazole or PTU (propylthiouracil) [14].

What are symptoms of Plummer’s disease?

Symptoms

• Fatigue.
• Frequent bowel movements.
• Heat intolerance.
• Increased appetite.
• Increased sweating.
• Irregular menstrual period (in women)
• Muscle cramps.
• Nervousness.

What do you need to know about the Jod Basedow syndrome?

Jod-Basedow phenomenon. The Jod-Basedow effect (also Jod-Basedow syndrome and Jod-Basedow phenomenon) is hyperthyroidism following administration of iodine or iodide, either as a dietary supplement or as contrast medium.

Who is at risk for the Jod Basedow effect?

Also, people who have Graves disease, toxic multinodular goiter, or various types of thyroid adenoma are also at risk of Jod-Basedow effect when receiving iodine, because the thyroid will then not respond to the negative feedback from increased thyroid hormones.

How does the Jod Basedow effect affect the thyroid?

However, (unlike the Wolff-Chaikoff effect), the Jod-Basedow effect does not occur in persons with normal thyroid glands, as thyroid hormone synthesis and release in normal persons is controlled by pituitary TSH secretion (which does not allow hyperthyroidism when extra iodine is ingested).

When does the Jod-Basedow phenomenon take place?

In individuals with normal thyroid function, they will undergo the escape phenomena (the gland escapes from this inhibitory effect and iodide organification resumes) after several days. Jod-Basedow Phenomenon: Iodine induced hyper thyroidism.