What bacteria does imipenem cover?

Imipenem is active against aerobic and anaerobic Gram positive as well as Gram negative bacteria including Pseudomonas aeruginosa and the Enterococcus.

Is imipenem always given with cilastatin?

Carbapenems are eliminated by the kidneys. Imipenem is hydrolyzed by renal tubular dipeptidase. Imipenem is therefore always combined with cilastatin, which inhibits this breakdown. Other carbapenems do not require coadministration with cilastatin because they are not metabolized by dipeptidase.

Why imipenem is given with cilastatin?

Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin (sye” la stat’ in), a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.

Does cilastatin prevent hydrolysis of imipenem?

Imipenem is hydrolyzed by renal tubular dipeptidase. Imipenem is therefore always combined with cilastatin, which inhibits this breakdown.

When do you use imipenem?

Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections.

Can imipenem be given alone?

Imipenem is indicated for the treatment of severe infections due to multiresistant organisms. Alone, or in combination with an aminoglycoside, it can be used for serious mixed infections including pulmonary, intraabdominal, and soft-tissue infections. It is generally well tolerated.

Can imipenem be given orally?

Imipenem is not absorbed by the oral route.

What should you assess before giving imipenem-cilastatin?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).

What is the difference between cilastatin and imipenem?

Imipenem is a carbapenem and beta-lactam antibiotic that inhibits bacterial cell wall synthesis through binding to penicillin binding proteins Cilastatin is a dehydropeptidase-I (DHP-I) inhibitor that prevents inactivation of imipenem by renal DHP-I Has no antibacterial activity Relebactam is a class A/C beta-lactamase inhibitor

When was imipenem-cilastatin-relebactam ( Recarbrio ) approved by the FDA?

Imipenem-cilastatin-relebactam (Recarbrio) is the combination of three molecules… Imipenem is a carbapenem and beta-lactam antibiotic that inhibits bacterial cell wall synthesis through binding to penicillin binding proteins FDA-approved July 17th, 2019 in patients 18 years and older with limited or no treatment options for…

When to use imipenem-cilastatin-relebactam-idstewardship?

FDA-approved July 17th, 2019 in patients 18 years and older with limited or no treatment options for… Imipenem-cilastatin-relebactam should be reserved for patients who have infection with drug-resistant bacteria Avoid use in patients on valproic acid (VPA) or divalproex sodium since a reduction in VPA levels may lead to seizures

What kind of infections can imipenem be used for?

Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. It is made from a combination of imipenem and cilastatin. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections.