What is an annular Elastolytic giant cell granuloma?

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized clinically by annular plaques with elevated borders and atrophic centers found mainly on sun-exposed skin and histologically by diffuse granulomatous infiltrates composed of multinucleated giant cells, histiocytes and …

What is Elastolytic granuloma?

Annular elastolytic giant cell granuloma is considered a distinct entity characterized by appearance of annular erythematous to skin-colored lesions preferentially on sun-exposed areas and histopathologically with a granulomatous reaction with elastolysis, phagocytosis of the elastic fibers, and multinucleate giant …

What are giant cells in granulomas?

Histiocytes (specifically macrophages) are the cells that define a granuloma. They often fuse to form multinucleated giant cells (Langhans giant cell). The macrophages in granulomas are often referred to as “epithelioid”.

What is Elastophagocytosis?

Elastophagocytosis is the phagocytosis of elastic fibers that can microscopically be seen in the cytoplasm of histiocytes, multinucleated giant cells, or both.

What is GA skin condition?

Granuloma annulare is a benign skin condition characterized by small, raised bumps that form a ring with a normal or sunken center. The cause of granuloma annulare is unknown and it is found in patients of all ages. The condition tends to be seen in otherwise healthy people.

What is interstitial dermatitis?

Interstitial granulomatous dermatitis (IGD) is a rare disease that clinically presents with a pruritic and painful rash revealing symmetric, erythematous, and violaceous plaques over the lateral trunk, buttocks, and thighs [1]. Fewer than 70 cases have been documented in the literature [2].

What causes giant cell granuloma?

The cause of peripheral giant cell granuloma is unknown, although local irritation due to dental plaque or calculus, periodontal disease, poor dental restorations, ill-fitting dental appliances, or dental extractions has been suggested to contribute to the development of the lesion.

Are granulomas permanent?

The natural history of foreign body granuloma varies depending on the cause. Foreign body granulomas and abscesses due to bovine collagen injections often regress spontaneously within 1–2 years [2–4]. Other types of foreign body granuloma may persist for decades.

What is dermal Elastolysis?

Abstract. Mid-dermal elastolysis (MDE) is a rare skin disorder clinically characterized by the appearance of diffuse fine wrinkling, most often of the trunk and arms. This entity is distinguished from other elastolytic disorders by its characteristic selective loss of elastic fibers of the mid dermis.

What are the side effects of granuloma?

Granulomas themselves don’t usually have noticeable symptoms. But the conditions that cause them, such as sarcoidosis, tuberculosis, histoplasmosis, and others, may create symptoms….Some of these include:

• Shortness of breath.
• Wheezing.
• Chest pain.
• Fever.
• Dry cough that won’t go away.

Is granuloma annulare an autoimmune disorder?

Granulomatous diseases and autoimmune diseases associations. Granuloma annulare is a benign disease of unknown etiology with a lymphocyte-mediated hypersensitivity type IV mechanism where an immunologic cell-mediated process or a primary collagen and/or elastin destruction have often been suggested [8].

How common is interstitial granulomatous dermatitis?

Where does annular elastolytic giant cell granuloma ( aegcg ) occur?

Annular elastolytic giant cell granuloma (AEGCG) is characterized by smooth-surfaced annular plaques with raised red borders and central hypopigmentation, occurring mostly on sun-exposed areas of the head, neck, and upper extremities. (Figure 1) Papular and reticulated variants have also been described. Lesions are usually asymptomatic.

Where does giant cell granuloma occur in the body?

Annular elastolytic giant cell granuloma (AEGCG) is characterized by smooth-surfaced annular plaques with raised red borders and central hypopigmentation, occurring mostly on sun-exposed areas of the head, neck, and upper extremities. (Figure 1) Papular and reticulated variants have also been described.

Are there any oral retinoids for annular elastolytic giant cell granuloma?

Oral antimalarials (hydroxychloroquine 200mg twice daily, chloroquine 250-500mg daily, or quinacrine 100-200mg daily) could alternatively be considered. For AEGCG, oral retinoid regimens include acitretin 25mg daily or isotretinoin 0.5mg/kg/day.

What is Pernick N annular giant cell granuloma?

Cite this page: Pernick N. Annular elastolytic giant cell granuloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumorannularelastolytic.html. Accessed June 15th, 2021. Erythematous or brown annular infiltrate in face, neck or dorsa of hands of elderly or heavily sun exposed individuals