What is amikacin 500 mg used for?

Amikacin Sulphate 500mg Injection is an antibiotic used to prevent or treat a wide variety of bacterial infections. These may include infections of the urinary tract, bones, and joints, lungs (eg. pneumonia), brain, blood, among others. It is also used in hospitalized patients to prevent infections.

How is amikacin injection given?

Amikacin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 or 12 hours (two or three times a day). When amikacin is injected intravenously, it is usually infused (injected slowly) over a period of 30 to 60 minutes.

Is amikacin a strong antibiotic?

The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus and Nocardia. Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection.

Is amikacin safe for babies?

Treatment of infants with amikacin give 15 mg/kg intravenously or intramuscularly to infants < 4 weeks old and 20 mg/kg to infants > this. Give a dose every 36 hours in infants less than 28 weeks gestation in the first week of life. Give all other infants a dose once-daily unless renal function is poor.

Is amikacin bad for kidneys?

Amikacin can harm your kidneys, and may also cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines. Tell your doctor about all your medical conditions and all the medicines you are using. If you need surgery, tell the surgeon ahead of time that you are using amikacin.

How long does it take for amikacin to work?

At the recommended dosage level, uncomplicated infections due to sensitive organisms should respond to therapy within 24 to 48 hours. If clinical response does not occur within three to five days, consideration should be given to alternative therapy.

Is amikacin IM painful?

See also Warning section. Nausea, vomiting, stomach upset, or loss of appetite may occur. Pain/irritation/redness at the injection site may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What are the side effects of amikacin?

Common side effects of Amikacin Sulfate Injection include:

• diarrhea,
• hearing loss,
• spinning sensation (vertigo),
• numbness,
• skin tingling,
• muscle twitching and convulsions,
• dizziness,
• ringing or roaring in the ears,

What is the major side effect of amikacin?

Tell your doctor right away if you have any serious side effects, including: numbness/tingling, muscle twitching or weakness, seizure. This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria.

How long can I take amikacin?

The usual duration of treatment is 7 to 10 days. It is desirable to limit the duration of treatment to short term whenever feasible. The total daily dose by all routes of administration should not exceed 15 mg/kg/day.

What is the side effect of amikacin injection?

Side Effects Nausea, vomiting, stomach upset, or loss of appetite may occur. Pain/irritation/redness at the injection site may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

How long does amikacin stay in your system?

In adults with normal renal function the plasma elimination half-life of amikacin is usually 2-3 hours. 94 – 98% of a single IM or IV dose of amikacin is excreted unchanged by glomerular filtration within 24 hours.

How much amikacin is in a 2 ml vial?

The dosage form is supplied as a sterile, colorless to light straw colored solution for IM or IV use. The 100 mg per 2 mL vial contains per each mL: 50 mg amikacin (as the sulfate), 0.13% sodium metabisulfite, 0.5% sodium citrate dihydrate, water for injection qs, with pH adjusted to 4.5 with sulfuric acid.

What do you need to know about amikacin sulfate injection?

DESCRIPTION: Amikacin sulfate injection, USP is a semi-synthetic aminoglycoside antibiotic derived from kanamycin.   It is O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→6)]-N3-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine sulfate (1:2). C22H43N5O13 • 2H2SO4                    M.W. 781.76

How is amikacin used in the treatment of cancer?

Therapy with amikacin may be instituted prior to obtaining the results of sensitivity testing. Surgical procedures should be performed where indicated. Consideration should be given to official guidance on the appropriate use of antibacterial Agents. Amikacin sulphate injection may be given intramuscularly or intravenously.

Are there any side effects to taking amikacin?

Amikacin resists degradation by certain aminoglycoside inactivating enzymes known to affect gentamicin, tobramycin, and kanamycin. Aminoglycosides in general have a low order of activity against Gram-positive organisms other than Staphylococcal isolates.