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Who makes Cosmegen?

Who makes Cosmegen?

COSMEGEN is a sterile lyophilized powder and is supplied in vials containing 0.5 mg (500 micrograms) of dactinomycin and 20.0 mg of mannitol. In the dry form the compound is an amorphous yellow powder. The solution is clear and gold-colored. ®Trademark of Recordati Rare Diseases Canada Inc.

How do you administer actinomycin?

administration, add 1.1 ml of preservative-free sterile water for injection to drug to yield 0.5 mg/ml. Don’t use a preserved diluent because precipitation may occur. Drug is highly toxic; avoid inhalation of powder or vapors and contact with skin or mucous membranes.

Is dactinomycin a Vesicant?

Dactinomycin is classified as a vesicant medication, meaning it can cause damage to tissue that comes in direct contact with the drug. It needs to be given with extreme caution by a qualified medical professional. You should notify medical personnel immediately if you have pain or swelling at the infusion site.

Who manufactures dactinomycin?

Manufacturer Name – Celon Laboratories Ltd.

How long can you keep Cosmegen at room temperature?

Further dilute the reconstituted product with 5% Dextrose Injection or 0.9% Sodium Chloride Injection to yield concentrations greater than 10 mcg/mL. Store at room temperature for no more than 4 hours from reconstitution to completion of injection or infusion. Discard after 4 hours. COSMEGEN does not contain a preservative.

What should you know about the use of Cosmegen?

Since COSMEGEN is extremely corrosive to soft tissues, it is intended for intravenous use. Inhalation of dust or vapors and contact with skin or mucous membranes, especially those of the eyes, must be avoided. Appropriate protective equipment should be worn when handling COSMEGEN.

How much dactinomycin is in a vial of Cosmegen?

Cosmegen (dactinomycin for injection) for intravenous use is a sterile, amorphous yellow to orange, lyophilized powder in a single-dose vial. Each vial contains 500 mcg of dactinomycin and 20 mg of mannitol.

When to discontinue the injection of Cosmegen?

Discontinue COSMEGEN for burning or stinging sensation or other evidence indicating perivenous infiltration or extravasation. Manage confirmed or suspected extravasation as follows: Terminate the injection or infusion immediately and restart in another vein.

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