How do you prevent peripheral neuropathy from isoniazid?

The present report gives results which show that the B-complex preparation is fully effective in preventing peripheral neuropathy in patients receiving the same high dosage of isoniazid, and that this is due to the small pyridoxine content of only 6 mg daily, and not to any of its other constituents.

Can isoniazid cause peripheral neuropathy?

Peripheral neuropathy is a rare adverse effect associated with isoniazid, and it occurs after the prolonged use of this drug [1]. This usually presents with paresthesias which can be accompanied by muscle aches, occasionally muscular weakness, and can progress to more severe symptoms such as ataxia [1].

Is isoniazid neuropathy reversible?

Isoniazid though a very effective treatment for tuberculosis can cause severe motor-dominant neuropathy which can be reversible with pyridoxine supplementation.

Which nutrient helps prevent peripheral neuritis which is a side effect of isoniazid INH )?

Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.

What vitamins should I take with isoniazid?

Supplementation with vitamin B6 is thought to help prevent isoniazid-induced niacin deficiency; however, small amounts of vitamin B6 (e.g. 10 mg per day) appear to be inadequate in some cases. People should consider using a daily multivitamin-mineral supplement during isoniazid therapy.

What are the side effects of isoniazid?

What are the possible side effects of isoniazid?

• sudden weakness or ill feeling, or fever for 3 days or longer;
• pain in your upper stomach (may spread to your back), nausea, loss of appetite;
• dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• vision changes, pain behind your eyes;

Why does B6 deficiency cause peripheral neuropathy?

Both overdose and deficiency may cause peripheral neuropathy. Pyridoxine deficiency causes injury of motor and sensory axons whereas an overdose of pyridoxine causes a pure sensory neuropathy or neuronopathy with sensory ataxia.

Does vitamin B6 cause peripheral neuropathy?

Long-term intake of high doses vitamin B6 can lead to nerve problems (29). High concentrations of vitamin B6 may result in severe peripheral sensory neuropathies and ataxia.

What are the main causes of neuropathy?

What are the causes of peripheral neuropathy?

• Physical injury (trauma) is the most common cause of acquired single-nerve injury.
• Diabetes is the leading cause of polyneuropathy in the United States.
• Vascular and blood problems that decrease oxygen supply to the peripheral nerves can lead to nerve tissue damage.

What medicines cause tingling in feet?

Other examples of medications that can cause tingling in the hands and feet include:

• heart or blood pressure drugs, such as amiodarone or hydralazine.
• anti-infection drugs, such as metronidazole and dapsone.
• anticonvulsants, such as phenytoin.

Who should not use isoniazid?

liver problems. severe liver disease. severe renal impairment. severe nausea and vomiting that has lasted a long time.

Which is a serious side effect of isoniazid?

Serious and sometimes fatal liver problems may occur during treatment with isoniazid or after you stop taking this medication, even months after stopping. The risk of liver problems is highest in adults between the ages of 35 and 65.

What are the risk factors for isoniazid induced neuropathy?

Isoniazid neuropathy develops in the presence of risk factors (HIV, alcoholism, diabetes, renal failure, malnutrition, pregnancy and lactation, neurotoxic medication) and manifests itself initially by burning feet. Pyridoxine is preventative in low dosage and curative in high dosage.

How much pyridoxine to take for isoniazid deficiency?

A 10 mg. dose of pyridoxine for each 100 mg. of isoniazid appears adequate to prevent both clinical and potential subclinical manifestations of pyridoxine deficiency. The administration of pyridoxine does not interfere with the antituberculous action of isoniazid.

How much pyridoxine is needed to prevent peripheral neuropathy?

Biehl and associates found that the daily administration of from 50 to 450 mg. of pyridoxine in conjunction with 1400 mg. of isoniazid effectively prevented the occurrence of peripheral neuropathy. “Effect of Isoniazid on Pyridoxine Metabolism,”.

Can a person with tuberculosis be treated with isoniazid?

In persons with isoniazid-sensitive Mycobacterium tuberculosis infection, drug regimens based on isoniazid are usually effective when persons adhere to the prescribed treatment. However, in persons with isoniazid-resistant Mycobacterium tuberculosis infection, drug regimens based on isoniazid have a high rate of failure.