What is the action of phenothiazine?

Phenothiazine: One of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmission (messages sent using the substance dopamine) within the brain.

What is a phenothiazine antiemetic?

Phenothiazines are broad-spectrum antiemetics that have efficacy against vomiting initiated by central and peripheral stimuli. From: Small Animal Clinical Pharmacology (Second Edition), 2008.

What is the action of antiemetic drug?

Antiemetic drugs are prescribed to help with nausea and vomiting that are side effects of other drugs. This may include drugs for anesthesia used during surgeries or chemotherapy for cancer. Antiemetic drugs are also used for nausea and vomiting caused by: motion sickness.

How do Thioxanthenes work?

Mechanism of Toxicity. Thioxanthenes work primarily by blocking postsynaptic dopamine-mediated neurotransmission by binding to dopamine (DA-1 and DA-2) receptors.

What is the mechanism of action of phenothiazine?

As anti-emetics, their mechanism of action is thought to be as antagonists of 5-HT and dopamine receptors in the chemoreceptor trigger zone. In addition, they act as an alpha-adrenergic antagonist.

Are there any side effects to taking phenothiazine?

Drowsiness and extrapyramidal side effects (unusual movement disorders) are common side effects. Some phenothiazine antiemetics are also used in the treatment of psychosis and schizophrenia. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

What causes nausea and vomiting with phenothiazines?

Normally, CTZ is stimulated by any toxic chemicals, bitter agents and many of the drugs like anticancer agents. All these chemicals act on dopamine receptors located on CTZ which stimulates nausea and vomiting.

What is the mechanism of action of promethazine?

Mechanism of Action of Promethazine Antiallergic actions: Promethazine mainly acts on H1 receptor. It competes with Histamine for H1 receptor. It does not affect the release of Histamine.