What is the pharmacokinetics of ACE inhibitors?
What is the pharmacokinetics of ACE inhibitors?
The predominant elimination pathway of ACE inhibitors is excretion via the kidneys. Therefore, renal insufficiency is associated with reduced elimination of most ACE inhibitors and, thus, altered pharmacokinetic properties.
How do ACE inhibitors mechanism of action?
ACE inhibitors work by interfering with the body’s renin-angiotensin-aldosterone system (RAAS). RAAS is a complex system responsible for regulating the body’s blood pressure. The kidneys release an enzyme called renin in response to low blood volume, low salt (sodium) levels or high potassium levels.
Where are ACE inhibitors absorbed?
Absorption of ACE inhibitors from small intestine and colon.
What is the half life of ACE inhibitors?
Tables/Images
| Generic Name | Brand Name | Half Life |
|---|---|---|
| Enalapril | Vasotec® | Pro-drug (Enalapril) healthy adults 2 hrs; congestive heart failure 3.4-5.8 Active metabolite (enalaprilat) 35-38 hrs |
| Fosinopril | Monopril® | Active Metabolite (fosinoprilat) 12 hrs |
| Lisinopril | Zestril® or Prinivil (R) | 12 hrs |
| Perindopril | Aceon® | 30-120 hrs |
Which is the best pharmacodynamics for angiotensin converting enzyme inhibitors?
Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update The angiotensin converting enzyme (ACE) inhibitors are widely used in the management of essential hypertension, stable chronic heart failure, myocardial infarction (MI) and diabetic nephropathy.
Which is the first ACE inhibitor for angiotensin II?
The first ACE inhibitor marketed, captopril, is still in widespread use today. Although newer ACE inhibitors differ from captopril in terms of pharmacokinetics and metabolism, all the ACE inhibitors have similar overall effects on blocking the formation of angiotensin II.
How are the pharmacokinetics of ACE inhibitors measured?
1The pharmacokinetics of most ACE inhibitors have been evaluated indirectly by the measurements of plasma ACE activity and circulating levels of angiotensin I and II.
What is the relationship between pharmacokinetics and PK?
This person is not on ResearchGate, or hasn’t claimed this research yet. The pharmacokinetic (PK) properties and the pharmacokinetic/pharmacodynamic (PK/PD) relationships for the angiotensin-converting enzyme (ACE) inhibitors (ACEIs), such as enalaprilat, benazeprilat, imidaprilat and ramiprilat, differ from those of conventional drugs.