Can gut GVHD be cured?

Symptoms of chronic GVHD of the stomach and intestines may get better with treatment. But it can take a long time.

What is gut GVHD?

Chronic graft-versus-host disease (GVHD) in the gut and GI tract is a common complication of a transplant using donor cells. Chronic GVHD can also affect the liver and, rarely, the pancreas.

What is GI GVHD?

Graft versus host disease (GvHD) is a condition that might occur after an allogeneic transplant. In GvHD, the donated bone marrow or peripheral blood stem cells view the recipient’s body as foreign, and the donated cells/bone marrow attack the body. There are two forms of GvHD: Acute graft versus host disease (aGvHD).

How is gut GVHD diagnosed?

Acute GVHD manifests primarily as skin, gut and liver disease with the gastrointestinal tract (GI tract) being the most commonly affected visceral organ. A clinical diagnosis of GI GVHD is frequently confirmed by finding apoptosis on mucosal biopsy.

How is histopathology used to diagnose GVHD?

Conclusions: Histopathologic examination remains the mainstay of diagnosis of gastrointestinal and liver GVHD and is interpreted in conjunction with clinical and laboratory data. Keywords: GVHD; Gastrointestinal pathology; Graft-vs-host disease; Liver pathology.

When does graft versus host disease ( GVHD ) occur?

Graft-versus-host disease (GVHD) occurs when alloreactive T cells from the donor attack healthy tissues in the recipient and arises almost exclusively in patients who have undergone allogeneic HSCT3.

Which is the most common site of acute GVHD?

The gastrointestinal system is among the most common sites affected by acute GVHD, and severe manifestations of acute GVHD of the gut portends a poor prognosis in patients after HSCT. Acute GVHD of the gastrointestinal tract presents both diagnostic and therapeutic challenges.

How is chronic GVHD related to inflammatory bowel disease?

Chronic GVHD rarely affects colon and causes submucosal fibrosis, mucosal calcification, focal fibrosis of lamina propria; may also have architectural glandular distortion similar to inflammatory bowel disease ( Mod Pathol 1998;11:513 )