Is the cornea well vascularized?

The cornea is avascular in healthy individuals; however, under specific pathological circumstances, new capillaries can grow within the cornea. There are three categories of neovascularization based on severity: superficial neovascularization, vascular pannus and deep stromal vascularisation.

What are the factors that make a normal avascular cornea vascular?

The normally avascular cornea may vascularize in situations in which a disequilibrium between angiogenic and antiangiogenic stimuli lead to a surplus of pro-angiogenic factors, such as vascular endothelial growth factor [VEGF], basic fibroblast growth factor [bFGF], and matrix metalloproteinases and a deficiency in …

What is an advantage of the cornea being avascular?

The cornea is a transparent avascular tissue that acts as a structural barrier and protects the eye against infections. [1] Along with the tear film, it provides proper anterior refractive surface for the eye.

What causes deep vascularization of the cornea?

Vascularization of the cornea is most frequently related to contact lens wear due to chronic hypoxia. The neovascularization is usually benign and appears as a superior corneal pannus with superficial vessels extending 1-2 mm into the cornea. However, deep vascular ingrowth is also possible,…

What do you need to know about corneal neovascularization?

Corneal Neovascularization can be defined as the excessive growth of blood vessels that occurs at the level of the cornea. The condition is often encountered in those who wear contact lenses.

How is corneal vascularization related to contact lens wear?

Treatment of Corneal Vascularization. Vascularization of the cornea is most frequently related to contact lens wear due to chronic hypoxia. The neovascularization is usually benign and appears as a superior corneal pannus with superficial vessels extending 1-2 mm into the cornea. However, deep vascular ingrowth is also possible,…

How are topical steroids used to treat corneal vascularization?

Topical steroids can promote vascular regression but require long-term treatment to be effective and therefore have the risk of causing elevated intraocular pressure and cataract formation.