What is a precursor to collagen?

Vitamin C plays a major role in the production of pro-collagen , the body’s precursor to collagen. Therefore, getting enough vitamin C is critical. As you probably know, citrus fruits like oranges, grapefruit, lemons, and limes are full of this nutrient.

What is the physiological role of collagen?

Collagen is a hard, insoluble, and fibrous protein that makes up one-third of the protein in the human body. In most collagens, the molecules are packed together to form long, thin fibrils. These act as supporting structures and anchor cells to each other. They give the skin strength and elasticity.

How is collagen formed in the body?

The body naturally makes its own collagen by breaking down dietary protein into amino acids. The amino acids are what build the various types of protein in the body, including collagen, according to Shannon Weston, a registered dietitian at the University of Texas Health School of Public Health in Houston.

Where does the biosynthesis of collagen take place?

Biosynthesis of collagen Collagen synthesis begins with transcription from DNA to messenger RNA within fibroblast nucleus (Fig. 7.13). Protein translation occurs in endoplasmic reticulum. Both magnesium and zinc trace minerals are needed for translation to occur.

What makes up the collagen in the reticular fibers?

They are composed of elastin – a protein that is flexible and allows many tissues in the body to resume their shape after stretching or contracting and are not visualized by an H&E. Reticular fibers are composed of collagen and form a delicate framework around nerve fibers, fat cells, lymph nodes, and smooth and skeletal muscle fibers.

How are reticulin stains used in connective tissue?

Reticulin stains use silver and rely on the argyrophillic properties of the fibers. Argyrophillic cells can adsorb silver but cannot reduce it. Adsorb = surface based process whereas absorb = permeation through the tissue. Argyrophillic cells need a reducer/developer to convert the invisible silver salts to a visible metallic silver. 1. 2. 3. 4.

How to determine cell selectivity of collagen synthesis?

To determine the cell selectivity of the 1,25 (OH) 2 D 3 inhibition of collagen synthesis, organ cultures of fetal rat calvariae were treated with 1,25 (OH) 2 D 3 for 22 h and then incubated with tritiated proline for the final 2 h of culture.