What is plasma-derived?
What is plasma-derived?
Plasma-derived products are made from donated human blood, from which the plasma or clotting proteins are separated or removed and made into clotting factor concentrates (specific clotting proteins, liquid or freeze dried as a powder) or fresh frozen plasma.
What is recombinant plasma?
Recombinant factor products are made in a laboratory using recombinant technology. These products are not made from human blood. Recombinant products offer a safer option than plasma-derived products because they avoid potential blood-borne transmission of infectious diseases.
What products are made from plasma?
It’s used in pharmaceutical products
| Plasma-based product | Used for |
|---|---|
| Intravenous Immunoglobulin IVIg | Treating some primary immune deficiency disorders |
| Antithrombin concentrate | Preventing blood clots during surgery or childbirth |
| Factor IX concentrate | Treating patients with inherited bleeding condition haemophilia B |
How are recombinant clotting factors made?
Recombinant clotting factors are made in a lab. They don’t come from blood. They are made with recombinant DNA technology. They are concentrated into a powder form that is then mixed with sterile water and injected.
How are plasma and recombinant products are made?
Plasma and Recombinant Products. A range of valuable products are manufactured from blood plasma through a process called fractionation, in which different types of proteins found in blood plasma are separated, purified and concentrated into therapeutic doses.
Which is safer plasma derived or recombinant products?
Recombinant products offer a safer option than plasma-derived products because they avoid potential blood-borne transmission of infectious diseases. In the United States, treatment with recombinant products is the standard of care.
Can a recombinant product be made from human blood?
Plasma-derived products. Plasma-derived concentrates are made from human blood which is donated by healthy volunteers and screened for safety. These products have been used since the 1970s. Recombinant products. Recombinant factor products are made in a laboratory using recombinant technology. These products are not made from human blood.
When to use recombinant or plasma derived factor VIII?
Both recombinant and plasma derived factor VIII products are available. Concentrated coagulation factor IX is used for the treatment and prophylaxis of bleeding in patients with haemophilia B. Both recombinant and plasma derived factor IX products are available.