Which glut transporter is in the kidney?

SGLT2 has been identified as a kidney-specific transporter. This transporter is responsible for reabsorption of 90% of glucose filtered at glomeruli [3]. It is responsible for the reabsorption of 180 g of glucose/day from the glomerular filtrate [4].

How is glucose transported in kidney?

Under normal circumstances, up to 180 g/day of glucose is filtered by the renal glomerulus and virtually all of it is subsequently reabsorbed in the proximal convoluted tubule. This reabsorption is effected by two sodium-dependent glucose cotransporter (SGLT) proteins.

Where is glucose transported in the nephron?

Under normal circumstances, up to 180 g/day of glucose is filtered by the renal glomerulus and virtually all of it is subsequently reabsorbed in the proximal convoluted tubule.

What happens to glucose in the nephron?

How are glucose transporters in the kidneys function?

Glucose transporters in the kidney in health and disease. The kidneys filter large amounts of glucose. To prevent the loss of this valuable fuel, the tubular system of the kidney, particularly the proximal tubule, has been programmed to reabsorb all filtered glucose.

Is the glucose transporter a high or low affinity isoform?

Is a high-frequency and low-affinity isoform. Expressed mostly in neurons (where it is believed to be the main glucose transporter isoform), and in the placenta. Is a high-affinity isoform, allowing it to transport even in times of low glucose concentrations.

What are the members of the glucose transporter family?

SGLT1 and SGLT2 function as glucose transporters in the intestine, heart, and kidney, whereas SGLT3 functions as a glucose sensor, mainly in intestine, spleen liver, kidney, and muscle. Other members of this family, SGLT4 and SGLT6, serve as inositol and multivitamin transporters and SGLT5 is the thyroid iodide transporter.

Is the regulation of glucose transport isoform specific?

Much evidence suggests that the regulation of glucose transport is also isoform specific. Regulation of transport occurs in response to altered energy requirements of tissues, so it is not surprising that one form of cellular stress, energy lack, is a potent regulator of glucose transport and transporter expression by different tissues.