What is Periampullary carcinoma?

Periampullary cancer is a cancer that forms near the ampulla of Vater, an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine. It consists of: ampullary tumour from ampulla of Vater.

Is Periampullary carcinoma curable?

The only potentially curative treatment for ampullary carcinoma is surgical resection. Complete tumor resection with negative margins (R0 resection) is a prerequisite for cure. It can be difficult to distinguish a primary ampullary carcinoma from other periampullary tumors preoperatively.

How is ampullary carcinoma treated?

The main treatment for ampullary cancer is surgery to remove the tumor. The Whipple procedure (also called a pancreaticoduodenectomy) is used. This is a major surgery where your surgeon removes the tumor in the affected part of the ampulla of Vater. Nearby tissues are often removed as well.

Which is the best treatment for periampullary cancer?

Treatment of periampullary cancer The treatment depends upon the stage of the disease and degree of jaundice. Surgery is the best possible option and can be considered if the cancer is diagnosed at a stage where it can be completely removed by surgery.

How is adjuvant therapy used to treat ampullary cancer?

Adjuvant Therapy for Ampullary Cancer. For periampullary cancers, including adenocarcinoma of the pancreas, ampulla, bile duct, and duodenum, a curative-intent pancreaticoduodenectomy provides the only chance for long-term survival.

Which is the best adjuvant treatment for colon cancer?

3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial. in The Lancet Oncology establish a new standard of care in the adjuvant treatment of stage III colon cancer.

Where does periampullary cancer occur in the body?

The term periampullary cancer includes cancer occurring around the ampulla of Vater. These are the cancer of the head of the pancreas, distal bile duct (cholangiocarcinoma), duodenum and ampulla. These cancers are clubbed together as a group because the clinical features and treatment are similar for them.