What is the difference between FEIBA and KCentra?

FEIBA® is current formulary activated prothrombin complex concentrate (aPCC) product. KCentra® is current formulary prothrombin complex concentrate (PCC) product. Kcentra™ contains clotting factors II, VII, IX and X. It contains heparin and use should be avoided in patients where heparin is contraindicated.

Is FEIBA a aPCC?

FEIBA NF and VH are considered aPCC products because they contain mostly activated factor VII along with mainly non-activated factors II, IX, and X.

Does FEIBA have heparin?

The product contains traces of factors of the kinin generating system. It contains no heparin. Reconstituted FEIBA contains 4 mg of trisodium citrate and 8 mg of sodium chloride per mL. FEIBA is manufactured from large pools of human plasma.

Which is better apixaban or dabigatran?

Apixaban had significantly lower rates of major bleeding in all comparisons, except when compared with dabigatran in patients with a CHA2DS2- VASc of 2 or 3. No significant interaction between treatment and baseline stroke or bleeding risks was found (Fig 4).

Which is the first reversal agent for dabigatran?

Idarucizumab is the first of these agents to be approved by the FDA for use in life-threatening bleeding or need for emergent procedures in patients on dabigatran.

How to reverse the effects of dabigatran at UCDMC?

A rebound in the INR may be observed after the administration as the effects of the anticoagulant are commonly longer than FFP. Supplemental parenteral calcium may be necessary to reverse citrate effects. ~4-6 hr Idarucizumab Antibody that directly neutralizes the effects of Dabigatran and has no effect on other anticoagulants Onset: Immediate.

Can You adorb dabigatran with activated charcoal?

Activated charcoal will adsorb this drug if the patient took it <2 hours ago. Here is a great review article on dabi. The blog Clot Connect MD put up these references: van Ryn J. Dabigatran etexilate – a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity.

Can a head bleed be reversed with dabigatran?

Just published study indicates that Dabi may not cause enlarged hematomas in head bleeds ( Circulation 2011;124:1654-1662) For a better understanding (if you are smarter than me) of how Dabigatran Etexilate affects lab assays, see this article Thromb Haemostasis 2012;107 (5) Douxfils et al.)