What is PNIPAM used for?

Therefore, PNIPAAm-based hydrogels are extensively investigated for applications on the controlled delivery of active molecules, in self-healing materials, tissue engineering, regenerative medicine, or in the smart encapsulation of cells.

What is the role of poly n isopropylacrylamide PNIPAM in controlled drug delivery system?

The role of poly(N-isopropylacrylamide) (PNIPAM) hydrogels in drug delivery. (a) PNIPAM hydrogel realeases the drug upon change in temperature (b) Biodegradable PNIPAM can be prepared by crosslinking of NIPAM with other degradeable polymers and can be be used for drug delivery.

What is Lcst of PNIPAM?

Abstract. Poly(N-isopropylacrylamide), PNIPAM, is a thermoresponsive polymer widely known for its lower critical solution temperature (LCST) phenomenon at 32 °C in aqueous solutions.

Why is poly nipam temperature-responsive?

Temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm), has been widely used in biomedical field because of its unique property, which is a reversible hydration and dehydration accompanying with dynamic conformational changes in the polymer chains by temperature change (Heskins & Guillet, 1968), across 32 …

Why is PNIPAm important as a smart polymer?

Among the smart polymers, thermoresponsive polymer poly (N-isopropylacrylamide) (PNIPAM) is very important because of its well defined structure and property specially its temperature response is closed to human body and can be finetuned as well.

How is PNIPAm used in cell culturing?

[…] Poly (N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering.

How are PNIPAm based films used in tissue engineering?

Poly (N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering. Many complex and expensive techniques have been employed to produce PNIPAm-based films for cell culturing.

What is the critical solution temperature of pNIPAM?

PNIPAm becomes hydrophobic and insoluble in water above a critical solution temperature (LCST), whereas it is soluble below this value 7, 8. The great interest for PNIPAm resides in the fact that its LCST value ranges between 32 to 35 °C, close to human body temperature 7, 8.

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