What are the pathogenesis of atherosclerosis?

Triglycerides, cholesterol and lipoproteins are implicated in the pathogenesis of coronary artery disease, especially atherosclerosis (9,10). Reduced concentrations of high density lipoprotein (HDL) and increased triglycerides have been shown to be responsible for the genesis of atherosclerotic lesions (17).

What are the theories of atherosclerosis?

Almost all the present investigations are still connected with one of the main three historical theories of atherosclerosis: 1) the incrustation theory, as developed by von Rokitansky, has now led to the many studies on the roles of thrombosis and platelets; 2) the irritation theory, as opposed to the preceding one by …

What is the first step in pathogenesis of atherosclerosis?

Lipid retention is the first step in the pathogenesis of atherosclerosis which is followed by chronic inflammation at susceptible sites in the walls of the major arteries lead to fatty streaks, which then progress to fibroatheromas which are fibrous in nature (Table 1) [5,6].

What is the pathogenesis of the disease atherosclerosis?

Pathogenesis of Atherosclerosis. Atherosclerosis is a multifocal, smoldering, immunoinflammatory disease of medium-sized and large arteries fuelled by lipids. Endothelial cells, leukocytes, and intimal smooth muscle cells are the major players in the development of this disease. The most devastating consequences of atherosclerosis,

How is atherosclerosis a response to injury theory?

Rev. Physiol. 1995. 57791-804). Atherosclerosis is a disease process which is triggered by sometimes subtle physical or chemical insults to the endothelial cell layer of arteries. The “Response to Injury Theory” now has widespread acceptance among scientific and medical scholars.

Is there a pathogenesis of atherosclerosis in the tunica intima?

Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: An updated review Bosn J Basic Med Sci. 2020 Feb 5;20(1):21-30.doi: 10.17305/bjbms

What is the role of endothelial cells in atherosclerosis?

Pathogenesis of Atherosclerosis The Response to Injury Theory The endothelial cells that line blood vessels provide an active, dynamic interface between the blood stream and the arterial wall.