What is the most common karyotype of a complete hydatidiform mole?

[12] In brief, complete moles are diploid (46,XX; 46,XY) while most partial moles are triploid (69,XXY; XXX; XYY). Triploid or tetraploid complete moles are androgenetic (since they lack maternal chromosomes) while tetraploid partial moles have maternal contributions.

What is seen in hydatidiform mole?

A molar pregnancy — also known as hydatidiform mole — is a rare complication of pregnancy characterized by the abnormal growth of trophoblasts, the cells that normally develop into the placenta. There are two types of molar pregnancy, complete molar pregnancy and partial molar pregnancy.

How is hydatidiform mole diagnosed?

Diagnosis of Hydatidiform Mole A pregnancy test is done. If women have a hydatidiform mole, results are positive, but no fetal movement and no fetal heartbeat are detected. Blood tests to measure the level of human chorionic gonadotropin (hCG—a hormone normally produced early in pregnancy) are done.

What is the karyotype of partial mole?

Most partial moles have a triploid karyotype: 69,XXX; 69,XXY; or 69,XYY (Fig. 2). Tetraploidy among partial moles has been described occasionally.

What is the karyotype of a hydatidiform mole?

With partial moles, the karyotype is usually triploid (69XXY), the result of fertilization of a normal egg by two sperm, one bearing a 23X chromosomal pattern and the other a 23Y chromosomal pattern. Complete hydatidiform moles usually occupy the uterine cavity and are rarely located in fallopian tubes or ovaries.

When does a complete hydatidiform mole show up?

Complete hydatidiform moles most commonly present with vaginal bleeding, usually occurring at 6 to 16 weeks of gestation in 90% of cases.

Can a hydatidiform mole be left intact after curettage?

Hysterectomy is an alternative to suction curettage in patients who do not wish to preserve fertility or are older and at increased risk for development of postmolar GTN. The adnexa may be left intact even in the presence of theca lutein cysts. In addition to evacuating the molar pregnancy]

What are the hCG levels for a hydatidiform mole?

Hydatidiform moles are commonly associated with markedly elevated hCG levels above those of normal pregnancy. Approximately 50% of complete moles have pre-evacuation hCG levels > 100,000 mIU/mL. However, a single hCG level is seldom helpful in differentiating a compete mole from another type of pregnancy.