What is prepulse inhibition?

Prepulse inhibition (PPI) refers to the ability of a low-intensity stimulus, or prepulse, to diminish the startle response elicited by a higher-intensity stimulus.

What is prepulse inhibition of acoustic startle?

Prepulse inhibition of the acoustic startle response (PPI) is a reduction in the magnitude of the acoustic startle response when a weak, non-startling sound—the prepulse—precedes an intense, potentially startling, sound [1,2,3].

What is prepulse inhibition of the startle reflex?

Background Prepulse inhibition of the startle reflex response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. This effect represents an operational index of sensorimotor gating and is found to be deficient in schizophrenia.

What is reduced prepulse inhibition?

Prepulse inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong reflex-eliciting stimulus (pulse), often using the startle reflex.

How is prepulse inhibition related to the startle response?

Prepulse inhibition: preceding stimulus attenuates the startle response. Prepulse inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong startling stimulus (pulse).

Which is a measure of prepulse inhibition ( PPI )?

Prepulse inhibition (PPI) is a measure of sensorimotor gating used to identify deficits in early stage information processing.

Who are people with deficits in prepulse inhibition?

Prepulse inhibition. Deficits of prepulse inhibition manifest in the inability to filter out the unnecessary information; they have been linked to abnormalities of sensorimotor gating. Such deficits are noted in patients suffering from illnesses like schizophrenia and Alzheimer’s disease, and in people under the influence of drugs,…

How is prepulse inhibition related to sensorimotor gating?

Prepulse inhibition is a measure of sensorimotor gating (i.e., the normal phenomenon whereby a mild sensory auditory or tactile input, termed the prepulse, suppresses the motor response to a subsequent strong sensory input, termed the pulse) and has been studied in patients with MSA, Parkinson’s disease and idiopathic REM behavior disorder.

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