How is valproic acid absorbed?

Valproic acid has excellent bioavailability and is absorbed through the intestine with no site specificity. The rate of absorption depends on the dosage form. Absorption is faster from the syrup and the gelatin capsule (Depakene). The enteric coated formulation (Depakote) was developed to minimize GI irritation.

Is valproate an agonist or antagonist?

Valproate and the 5-HT1A receptor. Ipsapirone is a selective 5-HT1A receptor partial agonist that induces hypothermia and secretion of ACTH and cortisol.

What is the mechanism of action of sodium valproate?

Valproate sodium is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, valproate sodium increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA.

What are the pharmacokinetics of Sodium Valproate ( VPA )?

The pharmacokinetics of the antiepileptic drug, sodium valproate (VPA), was investigated in 6 healthy volunteers after a single intravenous dose of 400 mg, as well as a solution and enteric‐coated tablets. The bioavailability of the enteric‐coated tablets was compared with that of normal tablets in 3 of these subjects.

What is the bioavailability of valproate capsules?

Estimates of bioavailability compared with an intravenous administration are in the range of 90% to 100%.18Several oral dosage forms are available, including capsules, syrup, delayed release tablets, and a “sprinkle” capsule containing enteric coated particles of valproate.

Is it safe to take sodium valproic acid?

Clinical pharmacokinetics of valproic acid–1988 Sodium valproate (valproic acid) has been widely used in the last decade and is now considered a relatively safe and effective anticonvulsant agent.

What is the concentration of valproic acid in CSF?

Once absorbed, valproic acid is largely bound to plasma proteins and has a relatively small volume of distribution (0.1 to 0.4 L/kg). Its concentration in CSF is approximately one-tenth that in plasma and is directly correlated with the concentration found in tears.