How long does reserpine take to work in horses?

Reserpine binds to the storage vesicles of neurotransmitters, particularly norepinephrine, serotonin and dopamine. It takes many hours or days to reach full effect and continues to have some subtle sedating effects for many days after the last dose.

What does reserpine do for horses?

Reserpine is used as a long-acting tranquilizer in horses. It is used to sedate excitable or difficult horses that are on enforced rest. It sometimes is used illicitly to sedate show horses, sale horses, or in other circumstances where a “quieter” horse might be desired.

Can horses take Prozac?

Fluoxetine 32 mg/ml injectable by NexGen is typically used in horses for the treatment of anxiety, aggression and compulsions such as cribbing and wind sucking. Horses treated with fluoxetine generally do not exhibit side effect or sedation and continue to function normally.

How much reserpine Can I give my horse?

Recommended doses of reserpine range from 1-4mg/500kg horse once daily and may be administered orally or by intramuscular injection. Doses of 5-10mg/500kg horse have resulted in severe toxicity. Signs of toxicity can occur within three to six hours of administration.

When to give reserpine to a show horse?

Reserpine is used as a long-acting tranquilizer to subdue excitable or difficult horses and has been used illicitly for the sedation of show horses, for-sale horses, and in other circumstances where a “quieter” horse might be desired. Currently, accurate tests are available that can determine if a horse has been given reserpine.

How does reserpine work on a horse’s brain?

Reserpine is an alkaloidal chemical derived from the plant Rauwolfia serpentina, sometimes used for long-term sedation of horses. Reserpine works by blocking the storage of some of the brain’s chemical messengers, including a neurotransmitter called norepinephrine.

What was name of horse that tested positive for reserpine?

In the wake of news that Clifton Promise, Jock Paget’s Land Rover Burghley CCI**** winner, tested positive for reserpine as well as Kevin McNab’s Burghley ride Clifton Pinot, we did some research on the drug. Thanks to Chronicle medical editor Joe Davis, DVM, his research assistant Juliet Graham and Barbara Forney, VMD, for their help.

Is there an antidote for reserpine for horses?

No antidote is available for reserpine toxicity.Drug interactions with reserpine can be life-threatening. Horses treated with reserpine within the previous 60 days may be at risk for profound hypotension (even death) when exposed to xylazine, detomidine or ketamine.