Does methadone cause swelling?

The development of edema in patients taking methadone has been reported after three to six months of methadone therapy. Cases of methadone causing edema and weight gain have been reported with both tablets and the liquid formulation.

Can methadone cause fluid retention?

This patient is compared to three others reported in the literature who also developed fluid retention shortly after being placed on methadone. We conclude that methadone induced edema can occur not only immediately, but also after years of uncomplicated treatment.

How does grapefruit juice affect methadone?

Various studies demonstrate that through CYP3A4 inhibition, grapefruit juice increases serum levels of opioids, such as methadone, though no clinically significant effects have been reported. Conclusions: Grapefruit juice inhibits the metabolism of methadone, raising its serum levels.

Why does methadone cause swelling and indegestion?

I stopped taking other pain medicines because of side effects to liver and other organs and heard there were no side effects to any organs when taking methadone and it was the best pain medicine available. I now take 10 mg in am and sometimes 10 mg in pm and I too have noticed excessive swelling all over my body.

Are there any side effects to taking methadone?

Accidental ingestion of even one dose of methadone hydrochloride tablets, especially by children, can result in a fatal overdose of methadone.Life-Threatening QT Prolongation: QT interval prolongation and serious arrhythmia (torsades de pointes) have occurred during treatment with methadone.

Why are my feet and ankles swollen after taking methadone?

To top it off my feet and ankles have been swollen since christmas. Just like everyone here the clinic told me it’s something other than methadone so I went to other Dr.s looking for an answer. All said it’s not a side effect of methadone. They ordered chest x-rays o check the heart, Blood test to check the liver, kidneys and for diabetes.

When to expect leg edema after methadone treatment?

These problems have usually been reported as occurring shortly after beginning methadone during the first episode of maintenance treatment. Occasionally, severe leg edema develops, and this can present significant functional problems (MacFadden, Maany, Dhopesh, & Woody, 1990).