What is the cell-based model of coagulation?

Our cell-based model of haemostasis replaces the traditional ‘cascade’ hypothesis, and proposes that coagulation takes place on different cell surfaces in three overlapping steps: initiation, amplification, and propagation.

What is cell-based model?

Cell-based models are mathematical models that represent biological cells as a discrete entities. They are used in the field of computational biology for simulating the biomechanics of multicellular structures such as tissues.

What is cell coagulation?

Coagulation is the process of making blood clot. This is an important and complex process that enables the blood to plug and heal a wound. This is how the body stops any unwanted bleeding. Coagulation involves the action of cells and coagulation (clotting) factors.

Why is the cell based model of coagulation important?

Conclusions – The cell‐based model of coagulation provides a description of coagulation that more likely reflects hemostatic processes as they occur in vivo. The hemostatic system is a vital protective mechanism that is responsible for preventing blood loss by sealing sites of injury in the vascular system.

Are there any new models of coagulation in vivo?

New models that include the contributions of cells in vitro and systems that involve real‐time in vivo imaging of coagulation have significantly modified current understanding of how hemostasis occurs in vivo. 1 Initially it was thought that exposure of blood to air was the initiator of coagulation after injury.

Is the Cascade Model of blood coagulation flawed?

The previous cascade model of blood coagulation, although refined and updated over the last few decades, is flawed as a description of how hemostasis occurs in vivo. The recently proposed model incorporates the vital role of cells in coagulation processes, and corrects deficiencies of the older cascade models.

Why does lack of regulation of hemostasis cause coagulation?

Lack of regulation of hemostasis has the potential to initiate coagulation (and consequently impede blood flow) at sites where no injury is present. Appropriate hemostasis consequently requires that coagulation control and regulation be localized specifically at a site of injury.